Our lab uses high throughput genomic, proteomic and ribonomic assays to understand fundamental processes of development and disease. We have engineered novel zebrafish and Drosophila model systems intorobotic-based screening platforms.
The lab’s current major area of focus is on the 48-member family of human nuclear receptor proteins (NRs). These coordinate homeostatic processes such as cholesterol uptake, steroid metabolism, growth,sexual differentiation, aging and behaviour. Common diseases arising from their malfunction include obesity, diabetes, depression, Alzheimer’s and cancer. NRs are regulated by small diffusible lipid hormones such as steroids (eg.estrogen) and lipophilic vitamins (eg VD). Their prevalence in disease, and ability to be modulated by small molecules, has made them one of the most successful drug targets. However, many of these drugs still have dangerous side effects, and about half of the NRs are still “orphans” in terms of successful drug targeting and endogenous ligand identification.
We have developed a highly disruptive new drug screening method for nuclear receptors that makes use of the pharmacological and genetic strengths of the zebrafish. We also have developed a mass spectrometry based- “pull down” method to purify the activated NRs to identify bound drugs, hormones or metabolites, as well as protein cofactors. We aim to understand how transcriptional regulation of nuclear receptors by ligands influence metabolic or neuronal health and disease and provide new insights into discovery of novel therapeutic approaches to treat or prevent these debilitating diseases, such as obesity, diabetes, atherosclerosis, asthma,depression and many different cancers.
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博士
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0
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开学时间：
秋季
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申请截止时间：
10月24日
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背景偏好：We are looking for candidates with experiences or interest in thefollowing areas: metabolic diseases (diabetes, obesity, NAFLD), biochemistry and molecular biology, RNA biology, bioinformatic data analysis, and geneticand disease animal models. Candidates should have in-depth technical knowledge in some areas of biological science, and expertise in molecular biology,biochemistry, metabolism, and cell culture. Basic knowledge of cell biology,cell signalling, mouse models and tissue immunohistochemical evaluation preferred. The successful candidate is expected to be highly motivated, have scientific independence, excellent writing skills and proficiency in English,and international peer-reviewed publications.
招生人：Prof. Dr. Henry Krause
招生电话：(416) 978-8602
招生邮箱：h.krause@utoronto.ca
招生网页：http://sites.utoronto.ca/krause/file/Krause_lab.html
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